Senior Director/Director - Head of In Vitro Pharmacology

Cambridge, Massachusetts, United States Full-time

Evelo Biosciences is seeking a talented and highly motivated Head of In Vitro Pharmacology to join our dynamic team.

This is an outstanding opportunity to join a fast-paced company in a new exciting field of medicine.  Evelo Biosciences is dedicated to improving the lives of patients globally through the development of monoclonal microbials.  As a member of the Evelo team, you will be a vital part of helping to shape Evelo’s vision: to develop transformative drugs through a new modality of medicines.

Reporting to the SVP of Immuno-Inflammation, the successful candidate will have the opportunity to partner closely with the Evelo executive leadership team to drive and support the strategic direction of the company’s discovery platform and product pipeline for inflammation and oncology. This individual will shape the strategy for the in vitro preclinical platform, leading a team that develops and delivers relevant in vitro assays using cell lines, and primary human and mouse cells.  The team will establish and oversee state-of-the-art, robust assays in which to evaluate a library of bacterial candidates. A key expectation of this critical role will be to develop the essential capacity and expertise to enable rapid evaluation of drug candidates through a wide variety of gut mucosal-relevant in vitro assays.

In addition, this individual will be responsible for managing a team of research scientists to deliver high-quality outcomes in this new field of drug discovery and development.

The successful candidate will possess exceptional scientific leadership and a deep understanding of pharmacology and immunology as it applies to inflammatory and oncology diseases, translational research, and drug discovery.  S/he will also have deep expertise in the development of robust cell-based assays for screening and mechanism-of-action studies.

Primary responsibilities:

  • Provide exceptional and rigorous scientific leadership to effectively lead an internal laboratory focused on the validation, design, and execution of in vitro assays, and development and characterization of new assays to support project advancement as necessary.
  • Manage a group of scientists and research associates in supporting programs. 
  • Work with and coordinate activities with group leaders across functional platforms to ensure high scientific quality of all in vitro studies and serve as in vitro representative on program teams
  • Stay up-to-date on relevant scientific literature and possess outstanding experimental skills
  • Foster scientific and technical innovation through hands-on collaboration and engagement with Evelo’s research teams.
  • Deliver results with a focus on progressing Evelo’s pipeline.
  • Participate and thrive in an interactive, dynamic, and team-oriented culture.

Qualifications and skills:

  • Ph.D. or equivalent in Immunology, Pharmacology, or a related field with 10+ years of relevant experience in the biotech/pharma setting is required.
  • Practical experience in the design, development, validation and execution of in vitro functional assays as well as bioanalytical assays for small or large molecule therapeutics is required.  
  • Strong knowledge in a broad range of cellular and biochemical assay technologies and instrumentation for drug discovery. Solid experience in cell culture of cell lines and primary cells required.
  • Experience with ex vivo analyses of in vivo studies highly desired.
  • Experience in microbiology and the microbiome field is a plus.
  • Demonstrated success in building, leading and managing scientific teams, including external collaborations.
  • The position requires a solid managerial track record, good communication skills and the ability to work well as part of a team. 
  • Provide development opportunities of team members and foster a culture of collaborative environment across department
  • Recognized scientific leadership as documented by references and external presentations.
  • Possesses outstanding presentation and communication skills.
  • Able to distill complex issues and clearly articulate innovative solutions.
  • Demonstrated effectiveness and growth in a fast-paced and dynamic team environment.
  • Work with project leads and senior leadership to develop project plans and execution strategy and to align team’s efforts with overall project and organizational goals.


About Evelo

Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadly applicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbials with defined therapeutic effects, Evelo can improve the speed, cost and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of disease with naturally occurring, safe and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015. For more information, please visit


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