Director, Human Resources

Cambridge, Massachusetts, United States Full-time

Evelo Biosciences is seeking an experienced and innovative Director of Human Resources


This is an outstanding opportunity to join a fast-paced company in a new exciting field of medicine.  Evelo Biosciences is dedicated to improving the lives of patients globally through the development of monoclonal microbials.  As a member of the Evelo team, you will be a vital part of helping to shape Evelo’s vision: in transforming therapies through a new modality of medicines.


Reporting into the Head of People and Operational Excellence, the successful candidate will have the ability to help build and shape the culture of a dynamic growing organization. As the Director of Human Resources, leveraging strong business acumen, substantial HR knowledge and experience, you will drive and lead initiatives that foster a high performing and innovative organization. In this hands-on role, you will be responsible for developing, delivering and executing the critical strategies for talent management, performance management, learning & development, employee relations, organizational effectiveness, total rewards and talent acquisition. This position will partner with internal and external resources to design and enhance programs that drive employee engagement and retention.

Primary Responsibilities:


  • Lead the design, delivery and prioritization of comprehensive, innovative and compliant Human Resources programs and processes that drive and support Evelo’s mission and strategy in the following areas:
    • Culture
    • Talent Acquisition
    • Talent Management
    • Total Rewards
    • Performance Management
    • Employee Relations
    • Learning & Development
    • Organizational Effectiveness
    • Workforce Planning
    • HR Systems and Analytics
    • Engagement and Retention


  • Partner with leaders on a variety of business critical strategic and operational issues
  • Serve as an engaged, accessible and trusted thought leader and change agent to all employees throughout the organization.
  • Develop and align Talent Acquisition, Talent Management and Performance Management strategies, brand and protocol to attract and retain exceptional talent
  • Ensure Total Rewards strategy and programs are competitive differentiators and drive an engaged and high performing culture
  • In partnership with Head of People and Operational Excellence, develop and lead Workforce Planning to ensure success of long term strategy as we evolve from a Research organization to progressing our programs through the clinic to commercialization.
  • Partner with managers in the oversight and management of employee relations while fostering a culture of compliance, transparent communication and coaching
  • Create foundational systems for tracking and measuring impact to business strategy of HR programs through analytics and metrics


Experience and Education:


  • Bachelor's degree in human resource management, business or a related field. Masters’ degree preferred.
  • 10 plus years of experience of progressively responsible roles in human resources, with significant knowledge and experience in Performance Management, Talent Acquisition, Talent Management, Total Rewards and Employee Relations.
  • Previous experience in biotech companies, including evolving early-stage, entrepreneurial companies required.


Desired skills and capabilities:


  • Hands-on, roll-up your sleeves, high-energy mission driven HR leader who thrives in an evolving and dynamic environment
  • Proven change agent with the ability to influence and collaborate
  • Adept at rapidly establishing credibility with leaders and peers
  • Viewed as a trusted strategic partner with solid business acumen and coaching skills
  • Knowledgeable and keeps abreast of leading edge practices and trends as well as policies, processes and laws.
  • Demonstrated success at developing and implementing high impact programs and solutions to further business strategy
  • Proven project management and organizational skills.
  • Outstanding communication and interpersonal skills (written, verbal & presentation).
  • Excellent analytical and reasoning skills.


About Evelo

Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadly applicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbials with defined therapeutic effects, Evelo can improve the speed, cost and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of disease with naturally occurring, safe and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015. For more information, please visit




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