Chief of Staff to the CEO

Cambridge, Massachusetts, United States Full-time

Evelo Biosciences is seeking a dynamic and high-energy Chief of Staff to the CEO to support our growing organization.



This is an outstanding opportunity to join a fast-paced company leveraging the previously untapped biology of the gut-body network to develop a new class of therapies that could transform the treatment of many major diseases, potentially providing profound benefits to patients and society. Evelo Biosciences is pioneering the development of therapies designed to act on the gut-body network – monoclonal microbials. Monoclonal microbials use naturally evolved pharmacology to work in the gut for effects throughout the body and comprise an entirely new class of effective, convenient and safe medicines to address the unmet needs of huge numbers of patients with serious diseases. As a member of the Evelo team, you will play a vital role in creating this new modality of medicine.


Reporting into the CEO with a dotted line to the Head of People and Operational Excellence, this critical role will help the CEO deliver Evelo’s vision to help people with serious disease across the globe by creating the world’s first monoclonal microbials. This will require a continued focus on excellence in execution. The Chief of Staff will help the CEO engage the organization and the Board of Directors to drive to results. Working closely with the Head of People and Operational Excellence they will shape and continuously improve leadership team interactions / communication and leading special projects across research and development. The successful candidate will be expected to participate in leadership team discussions across all aspects of the company and travel with the CEO to attend meetings with key external stakeholders. This role will provide great visibility to the operations of Evelo and could be a spring board to future leadership positions.


Desired skills and capabilities:

  • Proven ability to successfully navigate and thrive in an ambiguous, fast-paced and rapidly evolving global environment 
  • Possesses outstanding communication skills (written/verbal/presentation) coupled with strong executive presence
  • Demonstrated capability to influence key stakeholders while simultaneously driving to decisions and outcomes as necessary
  • Ability to establish credibility with cross functional teams in biotech Research and Development
  • Agile and strategic thinker with proven organizational and project management skills
  • Adept at process improvement to both existing systems and establishing new processes
  • Proven highly accountable driver with a willingness to take on ad hoc projects
  • Able to travel globally up to 50% of the time 

 Experience and Education:

  • Advanced degree (MBA, PhD, MD, JD etc.) required.
  • 5+ years of experience working in or serving the biotechnology or pharmaceutical industry required
  • Top tier management consulting experience strongly preferred
  • Previous experience in evolving early-stage, entrepreneurial companies’ a plus.


About Evelo

Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadly applicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbials with defined therapeutic effects, Evelo can improve the speed, cost and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of disease with naturally occurring, safe and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015. For more information, please visit




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